Fri Dec 08 2023

72 articles - From Friday Dec 01 2023 to Friday Dec 08 2023

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Endoscopy

Training in basic gastrointestinal endoscopic procedures: a European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology and Endoscopy Nurses and Associates (ESGENA) Position Statement.

9: ESGE and ESGENA recommend that GI endoscopy training units fulfil the ESGE KPIs for endoscopy units and, furthermore, be capable of providing the dedicated personnel, infrastructure, and sufficient case volume required for successful training within a structured training program. 10: ESGE and ESGENA recommend that trainers in basic GI endoscopic procedures should be endoscopists with formal educational training in the teaching of endoscopy, which allows them to successfully and safely teach trainees.

Pubmed   Journal   ReadQx 

J Hepatol

Improved assessment of donor liver steatosis using Banff consensus recommendations and deep learning algorithms.

Our findings support the use of Banff recommendations in daily practice and highlight the need for a granular analysis of their effect on liver transplantation outcomes. Impact and implications • We developed and validated the first automated deep-learning algorithms for steatosis standardized assessment based on the Banff Liver Working Group consensus recommendations. • Our algorithm provides an unbiased automated evaluation of steatosis, which will lay the groundwork for granular analysis of steatosis's short- and long-term effects on organ viability to identify clinically relevant steatosis cut-off for donor organ acceptance. • Implementing our algorithm in daily clinical practice will allow a more efficient and safe allocation of donor organs, aiming at improving the post-transplant outcomes of patients.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Am J Gastroenterol

Dye Chromoendoscopy Outperforms High-Definition White Light Endoscopy in Dysplasia Detection for IBD Patients: An Updated Meta-analysis of Randomized Controlled Trials.

Our updated meta-analysis supports DCE as a superior strategy in overall dysplasia detection in IBD, even with HD scopes. When expertise is available, DCE should be considered for surveillance colonoscopy in high-risk IBD patients, with the acknowledgment that virtual chromoendoscopy shows equivalence in recent studies. Further multicenter trials with multiple endoscopists with varying expertise levels and longer-term outcome data showing a reduction in cancer or cancer-related death are needed.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Lack of Effectiveness of Computer Aided Detection for Colorectal Neoplasia: A Systematic Review and Meta-analysis of Non-Randomized Studies.

CADe in colonoscopies neither improves the detection of colorectal neoplasia nor increases burden of colonoscopy in real-world, non-randomized studies, questioning the generalizability of the results of randomized trials.

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Bifidobacterium breve Bif195 ameliorates aspirin-induced gastric mucosal damage: A randomised, double blind, placebo-controlled crossover trial.

Bif195 reduces aspirin-induced gastric mucosal damage and may serve as a safe supplement during multiple-dosing aspirin treatment.

Pubmed   Journal   ReadQx 

Clinical trial: Clinical and endoscopic outcomes with ustekinumab in patients with Crohn's disease: Results from the long-term extension period of STARDUST.

STARDUST LTE is the first interventional ustekinumab efficacy study to show a favourable benefit-risk profile with preservation of clinical and endoscopic outcomes through Week 104 using flexible, algorithm-driven dose adjustment including de-escalation.

Pubmed   Journal   ReadQx 

Long-term effectiveness and acceptability of switching from intravenous to subcutaneous infliximab in patients with inflammatory bowel disease treated with intensified doses: The REMSWITCH-LT study.

Switching from IV to SC infliximab 120 mg every other week is safe and well accepted leading to low long-term risk of relapse. Tight monitoring and dose escalation should be recommended for patients receiving 10 mg/kg/6 weeks and 4 weeks, respectively.

Pubmed   Journal   ReadQx 

Low screening rates and high prevalence of osteoporosis in cirrhosis: A real-world retrospective analysis.

A minority of patients with cirrhosis were screened for osteoporosis. The majority screened had osteopenia or osteoporosis on DEXA scan. Less than a quarter of patients with osteoporosis were started on treatment. Real-world experience of oral bisphosphonate use did not reveal higher rates of gastrointestinal bleeding. There is room for improvement in al aspects of bone health care in cirrhosis.

Pubmed   Journal   ReadQx 

Am J Gastroenterol

Long-term natural history of autoimmune gastritis: results from a prospective, monocentric series.

AIG is a progressive disorder, with a virtually absent risk of gastric adenocarcinoma. Potential AIG patients should be monitored as they carry a high risk of evolving into overt AIG.

Pubmed   Journal   ReadQx 

The efficacy of metoclopramide for gastric visualization by endoscopy in patients with active upper gastrointestinal bleeding: double-blind randomized controlled trial.

Metoclopramide did not improve endoscopic visualization but decreased the need for second look EGD in patients with overall active UGIB. It improved gastric visualization in those with UGIB due to gastric lesions, primarily by improving visualization in the fundus. (ClinicalTrials.gov number NCT04771481).

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Accuracy of the enhanced liver fibrosis test in patients with type 2 diabetes mellitus and its clinical implications.

The high diagnostic performance of the ELF test for predicting advanced fibrosis in individuals with or without T2DM could address an unmet medical need for accurate assessment of liver fibrosis in patients with diabetes and NAFLD.

Pubmed   Journal   ReadQx 

Cardiovascular Safety of Ozanimod in Patients With Ulcerative Colitis: True North and Open-Label Extension Analyses.

No new cardiovascular safety signals were identified, consistent with findings from previous ozanimod studies. There were few major adverse cardiovascular events or thromboembolic events, which were unrelated or unlikely related to ozanimod. Ozanimod has a well-tolerated cardiovascular safety profile when prescribed in accordance with the label.

Pubmed   Journal   ReadQx 

Chronic Liver Disease and Cirrhosis Mortality Rates are Disproportionately Increasing in Younger Women in the US between 2000-2020.

Mortality rates due to CLD and cirrhosis in the U.S. are increasing disproportionately in younger women. This finding was driven by higher rates in Non-Hispanic White and Hispanic individuals, with variation between U.S. states. Future studies are warranted to identify the reasons for these trends with the ultimate goal of improving outcomes.

Pubmed   Journal   ReadQx 

Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans with Cirrhosis.

LSM predicts rates of HCC in patients with HCV cirrhosis after SVR at multiple cutoff levels and offers a single test to predict portal hypertension-related complications and HCC. Patients with LSM <5 kPa in the absence of diabetes mellitus had a low risk of HCC where surveillance could be discontinued.

Pubmed   Journal   ReadQx 

Regression of liver fibrosis in patients on hepatitis B therapy is associated with decreased liver-related events.

Antiviral therapy-induced liver fibrosis regression assessed by P-I-R score is associated with reduced liver-related events. This shows the utility of histologic fibrosis regression assessed by on-treatment P-I-R score as a surrogate endpoint for clinical events in patients with HBV-related fibrosis or early cirrhosis.

Pubmed   Journal   ReadQx 

Reliability and Responsiveness of Histologic Indices for the Assessment of Crohn's Disease Activity.

CD and UC indices were similarly reliable and responsive in measuring histologic CD activity. Exploratory index development did not offer benefit over current histologic instruments.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Anesthesia Choice and Its Potential Impact on Endoluminal Functional Lumen Imaging Probe Measurements in Esophageal Motility Disorders.

The use sevoflurane-based GAIA for diagnostic EndoFLIP may potentially lead to the misclassification of spastic disorders as Type I achalasia. Therefore, propofol-based TIVA should be considered over sevoflurane-based GAIA for sedation during the diagnostic test.

Pubmed   Journal   ReadQx 

Assessing the impact of center volume on the cost-effectiveness of centralizing ERCP.

The study's main findings remained unchanged while combining al model parameters in the PSA. Our findings show that HV centers have high-performance rates at lower costs, raising the need to consider the principle of centralization of ERCPs into HV centers to improve the quality of care.

Pubmed   Journal   ReadQx 

Association of direct oral anticoagulant and delayed bleeding with pharmacokinetics after endoscopic submucosal dissection.

The incidence of post-ESD bleeding taking DOAC was high, especially in aged patients and with high anti-coagulant effects. Measurement of pharmacokinetic parameters of DOACs may be useful in identifying patients at higher risk of post-ESD bleeding.

Pubmed   Journal   ReadQx 

ENDOSCOPIC SUBMUCOSAL DISSECTION WITH VERSUS WITHOUT TRACTION FOR PATHOLOGICALLY STAGED T1B ESOPHAGEAL CANCER: A MULTICENTER RETROSPECTIVE STUDY.

ESD with traction seems to be associated with higher odds of negative VM than ESD without traction for pathologically staged T1b EC, and future well-conducted prospective studies are warranted to establish the findings of the current study.

Pubmed   Journal   ReadQx 

Endoscopic Powered Resection Device for Residual Colonic Lesions: The First Multicenter, Prospective, International Clinical Study.

EPR is a safe and effective for benign, persistent, large (>20mm) scarred, colorectal adenomas and should be considered as an alternative treatment in lieu of surgery. Persistence rate of 46.7% show that more than one treatment are necessary for effective endoscopic treatment.

Pubmed   Journal   ReadQx 

The Impact of Transpancreatic Precut Sphincterotomy on the Quality of Endoscopic Retrograde Cholangiopancreatography in a Low-Volume Setting.

TPS can effectively enhance the quality of ERCP irrespective of practice volume.

Pubmed   Journal   ReadQx 

Gut

10-year follow-up results of the European Achalasia Trial: a multicentre randomised controlled trial comparing pneumatic dilation with laparoscopic Heller myotomy.

PD and LHM are equally effective even after 10 years of follow-up with limited risk to develop gastro-oesophageal reflux. Based on these data, we conclude that PD and LHM can both be proposed as initial treatment of achalasia.

Pubmed   Journal   ReadQx 

Compared to histamine-2 receptor antagonist, proton pump inhibitor induces stronger oral-to-gut microbial transmission and gut microbiome alterations: a randomised controlled trial.

Our study provides evidence that PPIs have a greater impact on the gut microbiome and oral-to-gut transmission than H2RAs, shedding light on the mechanism underlying the higher risk of certain diseases associated with prolonged PPI use.

Pubmed   Journal   ReadQx 

Dupilumab demonstrated efficacy and was well tolerated regardless of prior use of swallowed topical corticosteroids in adolescent and adult patients with eosinophilic oesophagitis: a subgroup analysis of the phase 3 LIBERTY EoE TREET study.

Dupilumab 300 mg once a week demonstrated efficacy and was well tolerated in patients with EoE regardless of prior STC use or inadequate response, intolerance and/or contraindication to STC.

Pubmed   Journal   ReadQx 

Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies.

Our study elucidates the mechanisms underlying enhancer dysregulation and deepens understanding of different tumourigenesis processes in distinct CCA subtypes, with potential significant therapeutics and clinical benefits.

Pubmed   Journal   ReadQx 

Single-cell transcriptomic analysis deciphers heterogenous cancer stem-like cells in colorectal cancer and their organ-specific metastasis.

We uncover a mechanism for organ-specific CRC metastasis.

Pubmed   Journal   ReadQx 

Hepatology

ALDOB/KAT2A interactions epigenetically modulate TGF-ß expression and T cell functions in hepatocellular carcinogenesis.

Our study has revealed a novel mechanism by which a metabolic enzyme in tumor cells epigenetically modulates TGF-ß signaling, thereby enabling cancer cells to evade immune surveillance and affect their response to immunotherapy.

Pubmed   Journal   ReadQx 

Determinants of clinical response to empirical antibiotic treatment in patients with cirrhosis and bacterial and fungal infections- Results from the ICA 'Global study' [EABCIR-Global Study].

Four out of 10 patients with cirrhosis do not respond to the first-line antibiotic therapy, leading to lower resolution of infections and higher mortality. Broader-spectrum antibiotics and strategies targeting systemic inflammation may improve prognosis in patients with high degree of inflammation, low serum albumin levels and severe liver impairment.

Pubmed   Journal   ReadQx 

Hyperinsulinemia, an overlooked clue, and potential way forward in metabolic dysfunction-associated steatotic liver disease.

The associated fasting hyperinsulinemia has been independently associated as a predictor of major adverse liver outcomes and major adverse cardiovascular events. In this review, we discuss the potential mechanism and entanglement between liver fibrosis and hyperinsulinemia and we hypothesise that the measure of fasting insulin could become a hepatic functional test within the armamentarium of non-invasive tests for the assessment of MASLD.

Pubmed   Journal   ReadQx 

Inhibition of CAF-1 histone chaperone complex triggers cytosolic DNA and dsRNA sensing pathways and induces intrinsic immunity of hepatocellular carcinoma.

Our findings suggest that CAF-1 is essential for HCC development, targeting CAF-1 may awaken the anti-cancer immune response and may work cooperatively with ICI treatment in cancer therapy.

Pubmed   Journal   ReadQx 

UBXN9 inhibits the RNA exosome function to promote T cell control of liver tumorigenesis.

Our results reveal a modality in which UBXN9 promotes the stimulatory RNA-induced RIG-I-IFN signaling that induces anti-tumor T cell response in liver tumorigenesis. Targeted manipulation of the UBXN9-RNA exosome circuit may have the potential to reinstate the immune control of liver tumor growth.

Pubmed   Journal   ReadQx 

J Hepatol

Comprehensive gene profiling of the metabolic landscape of humanized livers in mice.

Our work revealed a complex metabolic response landscape of human liver transcriptome and provided a novel resource to understand transcriptome dynamics of human liver in response to physiologically relevant metabolic stimuli ( Impact and implications Direct knowledge of the human liver transcriptome is currently very limited hindering the overall understanding of human liver pathophysiology. We combined a liver-specific humanized mouse model and long read direct RNA sequencing technology to establish a de novo annotation of the human liver transcriptome and identified a multitude of regulated metabolic pathways that were otherwise invisible using conventional technologies. The extensive regulatory information of human genes we provided would allow basic scientists to infer the disease relevance of their genes of interest and physician scientists to better pinpoint the changes in metabolic networks underlying a specific pathophysiology.

Pubmed   Journal   ReadQx 

NIS2+TM as a screening tool to optimize patient selection in metabolic dysfunction-associated steatohepatitis clinical trials.

While the use of FIB-4 alone did not lead to a significant improvement of the screening process, selecting patients using NIS2+ ™, a recently developed optimization of the NIS4® technology for the detection of at-risk MASH, showed improved performances by simultaneously reducing LBFRs and the overall cost of the trial, keeping a manageable number of patients needed to screen, without generating any bias in included patients' characteristics. This makes NIS2+ ™ an accurate and reliable screening tool for improving the recruitment of patients in future MASH clinical trials, and would lead to increased patient comfort and security, ensuring timely and cost-efficient completion of those trials.

Pubmed   Journal   ReadQx 

J Neurogastroenterol Motil

Esophageal Motility Abnormalities in Lung Transplant Recipients With Esophageal Acid Reflux Are Different From Matched Controls.

The strongest correlation with AET after LT was found to be esophageal peristaltic vigor. These results add to the understanding of reflux after LT and may help tailor an individualized treatment plan.

Pubmed   Journal   ReadQx 

The Effect of STW5 (Iberogast) on Reflux Symptoms in Patients With Concurrent Dyspeptic Symptoms: A Double-blind Randomized Placebo-controlled Crossover Trial.

We found some indications pointing towards a beneficial effect of STW5 on reflux symptoms in dyspeptic patients, with reduction of esophageal hypersensitivity as a potential underlying mechanism. Our findings will have to be confirmed in larger studies.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin Gastroenterol Hepatol

EXPANDING ROLE OF GASTROENTEROLOGY IN THE STAGING OF DIGESTIVE NEUROENDOCRINE TUMORS: UPDATES FROM THE AJCC VERSION 9 CANCER STAGING SYSTEM.

Pubmed   Journal   ReadQx 

EXPLORing the therapeutic ceiling in Crohn´s Disease: will combination pave the way?

Pubmed   Journal   ReadQx 

From Hirschowitz to 2023: Modern Endoscopy and Beyond.

Pubmed   Journal   ReadQx 

The colorectal cancer enigma and early life exposures.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

A Practical Guide to the Use of Upadacitinib in Ulcerative Colitis and Crohn's Disease.

Pubmed   Journal   ReadQx 

Collaborative Registries for Pediatric Crohn's Disease: A Leap Forward or More of the Same?

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Adenomyomatous hyperplasia of the ampulla of Vater.

Pubmed   Journal   ReadQx 

Low Incidence of Pulmonary Aspiration During Upper Endoscopy in Patients Prescribed a Glucagon-Like Peptide 1 Receptor Agonist.

Pubmed   Journal   ReadQx 

Mesalazine-induced obstructive intra- and extra-hepatic bile duct inflammation mimicking cholangiocarcinoma.

Pubmed   Journal   ReadQx 

Unusual Villiform Re-epithelialisation in Barrett's Esophagus following Endoscopic Treatment.

Pubmed   Journal   ReadQx 

Endoscopy

A tricky gastric lesion diagnosed by small-bowel capsule endoscopy.

Pubmed   Journal   ReadQx   PMC

Aspiration of tissues and ascites: the solution to endoscopic ultrasound-related duodenal perforation during pancreatic cancer sampling.

Pubmed   Journal   ReadQx   PMC

Cold snare for your polyps <10mm; cold snare for the planet.

Pubmed   Journal   ReadQx 

Multipolar adaptive traction allows diagnostic endoscopic submucosal dissection for colonic lesions with focal invasive area.

Pubmed   Journal   ReadQx   PMC

Gastroenterology

A Case of Mistaken Identity.

Pubmed   Journal   ReadQx 

A Practical Guide to Evaluating and Using Big Data in Digestive Disease Research.

Pubmed   Journal   ReadQx 

An Unusual Cause of Acute Pancreatitis.

Pubmed   Journal   ReadQx 

Concepts and Controversies in EoE: What's coming down the pipe.

Pubmed   Journal   ReadQx 

Sex-Discordant Fecal Microbiota Transplantation for C. difficile may increase risk of post-infection irritable bowel syndrome.

Pubmed   Journal   ReadQx 

Unveiling the protective role of BTNL-selected d T cells in inflammatory bowel disease.

Pubmed   Journal   ReadQx 

Watery diarrhea and various and variable lesions in the intestine.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

A case of idiopathic retroperitoneal fibrosis (Ormond's disease) diagnosed by transduodenal endoscopic ultrasound-guided fine needle aspiration/biopsy (EUS-FNA/FNB).

Pubmed   Journal   ReadQx 

Top tips for successful endoscopic hemorrhoid banding.

Pubmed   Journal   ReadQx 

Gut

EUS-guided gallbladder drainage in acute cholecystitis: long-term problems with surgical approach.

Pubmed   Journal   ReadQx 

Extent of normal polyp resection margin: a possible quality measure for polyp resection.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Clin Gastroenterol Hepatol

Fecal calprotectin profiles in Crohn's disease: a longitudinal data analysis.

Pubmed   Journal   ReadQx 

The risk of polysaccharide hemostatic powder for peptic ulcer bleeding.

Pubmed   Journal   ReadQx 

What the new definition of MASLD left behind: Dual aetiology with viral hepatitis.

Pubmed   Journal   ReadQx 

Gastroenterology

Consideration of Defining the Detailed Target Population and Mortality Rates: Key Factors in Achieving Generalizable Results.

Pubmed   Journal   ReadQx 

Gut

Response to: Correspondence on 'Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: still needed further discussion' by Wang et al.

Pubmed   Journal   ReadQx 

J Hepatol

ARID3A variant and the risk of primary biliary cholangitis in a Central European cohort.

Pubmed   Journal   ReadQx 

Beyond Body Weight: Diversified Presentation of MASLD in Lean, Overweight, and Obese Participants.

Pubmed   Journal   ReadQx 

Increase in HDV replication during steroid therapy - potential implications for testing and treatment strategies.

Pubmed   Journal   ReadQx 

Preliminary Fatty Liver Disease Grading Using General-Purpose Online Large Language Models: ChatGPT-4 or Bard?

Pubmed   Journal   ReadQx 

Suboptimal hydration status increases the risk of incident MAFLD: a pediatric cohort study.

Pubmed   Journal   ReadQx 

Ultrasensitive HBsAg testing predicts HBsAg seroreversion outcomes: considerations for new and existing therapies.

Pubmed   Journal   ReadQx